Investigation of plant flavonoids as potential dengue protease inhibitors
نویسندگان
چکیده
منابع مشابه
3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors
Dengue is a severe mosquito-borne viral infection causing half a million deaths annually. Dengue virus NS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues 4a-4j were synthesized and screened in silico against DENV2 NS2B/NS3 protease to elucidate their binding mechanism and orientation around the active s...
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Dengue infection has turned into a serious health concern globally due to its high morbidity rate and a high possibility of increase in its mortality rate on the account of unavailability of any proper treatment for severe dengue infection. The situation demands an urgent development of efficient and practicable treatment to deal with Dengue virus (DENV). Flavonoids, a class of phytochemicals p...
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It has been recognized for many years that the nutritive value and protein digestibility of many plant proteins, particularly those derived from legumes, are very poor unless subjected to cooking or some other form of heat treatment (Liener & Kakade, 1969). This beneficial effect of heat has beem generally attributed, at least in part, to the destruction of a unique class of proteins which have...
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Dengue virus (DENV) protease is an attractive target for drug development; however, no compounds have reached clinical development to date. In this study, we utilized a potent West Nile virus protease inhibitor of the pyrazole ester derivative class as a chemical starting point for DENV protease drug development. Compound potency and selectivity for DENV protease were improved through structure...
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ژورنال
عنوان ژورنال: Journal of Herbmed Pharmacology
سال: 2020
ISSN: 2345-5004
DOI: 10.34172/jhp.2020.46